Variant | Gene | Disease | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
C | 0.720 | CausalMutation | CLINVAR | Prospective enterprise-level molecular genotyping of a cohort of cancer patients. | 25157968 | 2014 |
|||||||
|
|
T | 0.720 | CausalMutation | CLINVAR | Major clinical response to a BRAF inhibitor in a patient with a BRAF L597R-mutated melanoma. | 23715574 | 2013 |
|||||||
|
|
C | 0.720 | CausalMutation | CLINVAR | Clinical, pathologic, and biologic features associated with BRAF mutations in non-small cell lung cancer. | 23833300 | 2013 |
|||||||
|
|
C | 0.720 | CausalMutation | CLINVAR | Activity of the oral MEK inhibitor trametinib in patients with advanced melanoma: a phase 1 dose-escalation trial. | 22805292 | 2012 |
|||||||
|
|
T | 0.720 | CausalMutation | CLINVAR | Activity of the oral MEK inhibitor trametinib in patients with advanced melanoma: a phase 1 dose-escalation trial. | 22805292 | 2012 |
|||||||
|
|
C | 0.720 | CausalMutation | CLINVAR | BRAF and RAS mutations in human lung cancer and melanoma. | 12460918 | 2002 |
|||||||
|
|
C | 0.720 | CausalMutation | CLINVAR | Clinical characteristics of patients with lung adenocarcinomas harboring BRAF mutations. | 21483012 | 2011 |
|||||||
|
|
C | 0.720 | CausalMutation | CLINVAR | This study shows that cells harboring BRAF(L597R) mutants are sensitive to MEK inhibitor treatment, providing a rationale for routine screening and therapy of BRAF(L597R)-mutant melanoma. | 22798288 | 2012 |
|||||||
|
|
T | 0.720 | CausalMutation | CLINVAR | BRAF and RAS mutations in human lung cancer and melanoma. | 12460918 | 2002 |
|||||||
|
|
T | 0.720 | CausalMutation | CLINVAR | Mutations of the BRAF gene in human cancer. | 12068308 | 2002 |
|||||||
|
|
T | 0.720 | CausalMutation | CLINVAR | This study shows that cells harboring BRAF(L597R) mutants are sensitive to MEK inhibitor treatment, providing a rationale for routine screening and therapy of BRAF(L597R)-mutant melanoma. | 22798288 | 2012 |
|||||||
|
|
T | 0.720 | CausalMutation | CLINVAR | Clinical characteristics of patients with lung adenocarcinomas harboring BRAF mutations. | 21483012 | 2011 |
|||||||
|
|
T | 0.720 | CausalMutation | CLINVAR | Missense mutations of the BRAF gene in human lung adenocarcinoma. | 12460919 | 2002 |
|||||||
|
|
C | 0.720 | CausalMutation | CLINVAR | Kinase-impaired BRAF mutations in lung cancer confer sensitivity to dasatinib. | 22649091 | 2012 |
|||||||
|
|
0.720 | GeneticVariation | BEFREE | This study shows that cells harboring BRAF(L597R) mutants are sensitive to MEK inhibitor treatment, providing a rationale for routine screening and therapy of BRAF(L597R)-mutant melanoma. | 22798288 | 2012 |
||||||||
|
|
0.720 | GeneticVariation | BEFREE | Among 41 response-evaluable patients, 2 (5 %) patients with cutaneous melanoma (one with BRAF L597R mutant melanoma) had partial responses. | 27650277 | 2017 |
||||||||
|
|
T | 0.720 | CausalMutation | CLINVAR | Kinase-impaired BRAF mutations in lung cancer confer sensitivity to dasatinib. | 22649091 | 2012 |
|||||||
|
|
T | 0.720 | CausalMutation | CLINVAR | Prospective enterprise-level molecular genotyping of a cohort of cancer patients. | 25157968 | 2014 |
|||||||
|
|
T | 0.720 | CausalMutation | CLINVAR | Genetic predictors of MEK dependence in non-small cell lung cancer. | 19010912 | 2008 |
|||||||
|
|
C | 0.720 | CausalMutation | CLINVAR | Major clinical response to a BRAF inhibitor in a patient with a BRAF L597R-mutated melanoma. | 23715574 | 2013 |
|||||||
|
|
C | 0.720 | CausalMutation | CLINVAR | Missense mutations of the BRAF gene in human lung adenocarcinoma. | 12460919 | 2002 |
|||||||
|
|
C | 0.720 | CausalMutation | CLINVAR | Alterations in genes of the EGFR signaling pathway and their relationship to EGFR tyrosine kinase inhibitor sensitivity in lung cancer cell lines. | 19238210 | 2009 |
|||||||
|
|
C | 0.720 | CausalMutation | CLINVAR | Genetic predictors of MEK dependence in non-small cell lung cancer. | 19010912 | 2008 |
|||||||
|
|
C | 0.720 | CausalMutation | CLINVAR | Mutations of the BRAF gene in human cancer. | 12068308 | 2002 |
|||||||
|
|
T | 0.720 | CausalMutation | CLINVAR | [Long-term results following surgery or radioiodine treatment of solitary autonomous adenoma of the thyroid gland]. | 2493360 | 1989 |